Endocrine Abstracts

Introduction: Alterations in foetal growth lead to neonatal health risks and favour metabolic diseases during adult life. Therefore, the study of birth weight determination and its modifications is crucial for metabolic diseases prevention. Placental growth is a key factor in foetal growth. It has been suggested that insulin and the IGF system play an important role in foetal growth and placental development and function. Although, insulin and IGFs in the umbilical cord blood ...

Considered as the biggest public health problem, the pandemic growth of obesity is associated to decline of male fertility potential over the last 50 years. Thus far, the effect of weight loss on semen parameters is still controversial and poorly understood. In this study we report the effect of significant weight loss on semen parameters of two obese men with metabolic syndrome. The patients followed to a very low-calorie ketogenic diet (VLCKD) according to a commercial weigh...

Introduction: Fine needle biopsy (FNB) is a very important diagnostic tool in the assessment of thyroid nodules and plays a prominent role in therapeutic approach. It has a sensitivity around 83 to 85% and a specificity around 80 to 92%.Aims: To correlate cytological (FNB) and final histopathological data in patients with nodular thyroid pathology.Methods: A retrospective study of patients who underwent surgical procedure from Janu...

Introduction: Gastric endocrine tumors (GET) are rare. Type 1 tumors are non-functioning, almost exclusively benign lesions, usually presenting as multiple polyps, usually <1 cm in diameter, which arise from gastric enterochromaffin-like cells in response to chronically elevated gastrin, secondary to (auto-immune) atrophic fundic gastritis. These tumors were traditionally treated with total gastrectomy, like adenocarcinomas. Currently, surveillance or endoscopic treatment ...

Obesity is growing fast worldwide. Although environmental factors play a major role, endocrine dysfunction may contribute to the weight gain. We report an invasive macroprolactinoma diagnosed in obesity setting. A 35-year-old male was referred to our endocrine outpatient department due to grade 2 obesity (IMC 38.4 Kg/m2). His weight was increasing since the beginning of his professional activity at the age of 20 due to a sedentary lifestyle. On physical examination he had an h...

Introduction: POEMS syndrome is a rare multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder and skin changes. Different endocrinopathies are found in 58-80% of patients, however, its pathophysiology remains unknown. Hypogonadism (primary and secondary) is the most common endocrinopathy (79% of patients), with other abnormalities including hyperprolactinemia (56%), primary hypothyroidism (54%), abnormal glu...

Aim: Dose corrected for thyroid gland size is one of the methods used to determine radioactive iodine (RAI) activity for patients with Graves disease (GD). This study was aimed to investigate the real-world success rate of this method and the predictors of success after first treatment.Methods: This is a retrospective study of 80 patients with GD treated between 2014 and 2020 in a tertiary referral hospital in Almada, Portugal. The successful group was d...

Introduction: The best timing for PRRT (peptide receptor radionuclide therapy) in the case of pancreatic neuroendocrine tumors (panNETs) is still to define, as randomized prospective trials are lacking. Recent studies suggest that some systemic therapies can affect response to PRRT, favoring an earlier use of the latter.Objective: To determine the efficacy and toxicity of PRRT, comparing its results when used as a second line systemic therapy (a...

Background: Papillary thyroid cancer (PTC) is the most frequent type of well-differentiated thyroid cancer (WDTC) and frequently poses a management dilemma. Its indolent behavior associated with high long term survival support the trend towards a more conservative management approach. The authors present a case of isolated bone metastases as the form of presentation of papillary thyroid carcinoma. A 61-year-old man was admitted with complaints of lower back pain for the previo...

Introduction: Intrauterine growth is a biological process regulated by maternal, placental, and foetal endocrine signals. Birth weight is an indicator of the health of the newborn. Alterations in foetal growth lead to perinatal health risks and favour metabolic diseases during adult life. Therefore, the study of endocrine factors determining birth weight, such as ghrelin is an important issue. Ghrelin may exist as two molecular forms, desacyl ghrelin (DAG) and acyl ghrelin (AG...